Cell Symposia: Microbiome and Host Health

It is now well appreciated that more microbes than actual human cells exist in and on the human body and that these microbes represent a vastly higher number of genes and gene products than are encoded by the host. The microbiome, defined as the host-inhabiting microbes and their genes and genomes, is a complex system characterized by various microbe-microbe and host-microbe interactions. These interactions influence various aspects of host physiology, and when in homeostasis, the microbiome contributes significantly to maintaining host health. However, both extrinsic factors (such as antibiotics) and intrinsic factors (such as host genetics) can cause perturbations to the system, leading to alterations in host physiology with potential adverse affects on host health.

This meeting aims to explore the composition, diversity, and dynamics of the microbiome; to examine the microbiome's influence on various aspects of host physiology; to understand the forces that perturb the microbiome-host balance; to outline the basis of diseases resulting from alterations to the microbiome; and, coming full circle, to discuss therapeutic approaches to how the host-microbiome balance, and thus host health, can be restored. The meeting will bring together researchers who have been delving into the microbial aspects of this system with researchers who study the host's physiology in health and disease, including infection, immunity, metabolism, and cancer.

Final Program

Sunday, May 12, 2013
11: 00 Registration, White Plains Foyer
14:00 – 14:10 Opening Remarks, White Plains 3,4,5
Session 1: Composition and Diversity of the Microbiome
14:10 - 14:45 Rob Knight, University of Colorado, USA
Effect size and cross-species translatability of microbiome studies [Inv.1]
14:45 - 15:20 Peer Bork, EMBL Heidelberg, Germany
Metagenomic analysis of the human gut microbiome: Variation, stratification and associations with disease [Inv.2]
15:20 - 15:35 Short Talk: N. Segata, Harvard School of Public Health, USA, University of Trento, Italy
Automating and improving taxonomic assignment with a high-resolution microbial phylogeny for microbiome studies [O1]
15:35 - 15:50  Short Talk: J.M. Fettweis, Vaginal Microbiome Consortium at VCU,  Virginia Commonwealth University, USA
Species diversity of the human vaginal microbiome [O2]
15:50 - 16:20 Coffee Break, New Orleans 1,2,3 & Nashville Room
16:20 - 16:55 Elhanan Borenstein, University of Washington, USA
Towards a predictive systems-level model of the human microbiome [Inv.3]
16:55 - 17:10 Short Talk: K. Hase, The University of Tokyo, Japan, RCAI, Japan
Commensal microbiota shapes the gut immune system through epigenetic [O3]
17:10 - 17:25 Short Talk: J. Oh, National Institutes of Health, USA
Primary immunodeficiencies alter the landscape of the human skin microbiome [O4]
17:30 Welcome Reception, New Orleans 1,2,3 & Nashville Room
Monday, May 13, 2013
08:00 - 08:30 Registration, White Plains Foyer
08:30 - 09:20 Keynote Presentation: Skip W. Virgin, Washington University School of Medicine, USA
Interactions between the mammalian virome, disease susceptibility genes, and the phenome [Inv.4]
Session 2: Microbiome in Health
09:20 - 09:55 Fredrik Bäckhed, University of  Gothenburg, Sweden
Gut microbial regulation of glucose metabolism [Inv.5]
09:55 - 10:25 Coffee Break, New Orleans 1,2,3 & Nashville Room
10:25 - 11:00 Dennis L. Kasper, Harvard Medical School, USA
Plasmacytoid dendritic cells mediate immunoregulation by the microbiota [Inv.6]
11:00 - 11:35 Sven Pettersson, Karolinska Institutet,Sweden
The gut microbiome and its role in mammalian development in early life [Inv.7]
11:35 - 12:10 Yasmine Belkaid, National Institute of Allergy and Infectious Disease, NIH, USA
Compartmentalized control of tissue immunity by commensals [Inv.8]
12:10 - 15:30 Poster Session I & Lunch, New Orleans 1,2,3 & Nashville Room
Session 3: Perturbations to the Microbiome
15:30 - 16:05 Ruth E. Ley, Cornell University, USA
Host control of the microbiome [Inv.9]
16:05 - 16:40 Philippe Sansonetti, Institute Pasteur, France
From symbiosis to homeostasis, from danger signaling to pathogenesis: Novel facets of gut cellular microbiology [Inv.10]
16:40 - 17:10 Coffee Break, New Orleans 1,2,3 & Nashville Room
17:10 - 17:45 Sarkis K. Mazmanian, California Institute of Technology, USA
Specific and stable colonization by Bacteroides of the gut microbiota [Inv.11]
17:45 - 18:00 Short Talk: F. Cabreiro, University College London, UK
Metformin retards aging in the nematode C. elegans by altering microbial folate and methionine metabolism  [O5]
18:00 - 18:15 Short Talk: Y. Soen, Weizmann Institute of Science, Israel
Bacterial mediated prevention of transgenerational inheritance of response to stress in flies [O6]
19:30 - 21:30 Meet the Speakers Dinner, Rios Restaurant & Bar
Tuesday , May 14, 2013
Session 4: Microbiome in Disease, White Plains 3,4,5
09:00 – 09:35 Wendy S. Garrett, Harvard School of Public Health, Harvard Medical School, and Dana-Farber Cancer Institute, USA
Gut microbiota in colitis and colorectal cancer [Inv.12]
09:35 - 09:50 Short Talk: E. Elinav, Weizmann Institute of Science, Israel , Yale University, USA
Transmissible cancer mediated by microbiome-induced activation of epithelial IL-6 signaling [O7]
09:50 - 10:05 Short Talk: A.D. Kostic, Harvard Medical School, USA, Broad Institute of M.I.T. and Harvard, USA
Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor immune microenvironment [O8]
10:05 - 10:35 Coffee Break, New Orleans 1,2,3
10:35- 11:10 Eric Pamer, Memorial Sloan-Kettering Cancer Center, USA
Intestinal microbiota and immune defense against infection [Inv.13]
11:10 - 11:25 Short Talk: A.S. Bhatt, Broad Institute, USA, Dana-Farber Cancer Institute, USA
“The gut, perturbed” – Sequence-based discovery of a novel, disease-associated bacterium in a post-stem cell transplantation colitis syndrome [O9]
11:25 - 12:00 Kenya Honda, RIKEN IMS, Japan
Clostridia strains from human microbiota for Treg induction [Inv.14]
12:00 - 15:30  Poster Session II & Lunch, New Orleans 1,2,3 & Nashville Room
Session 5: Exploring Therapeutic Opportunities
15:30 - 16:05 Michael Fischbach, University of California San Francisco, USA
A gene-to-molecule approach to the discovery and characterization of natural products [Inv.15]
16:05 - 16:40 Peter J. Turnbaugha, Harvard University, USA
Drug metabolism and resistance in the human gut microbiome [Inv.16]
16:40 - 16:55 Short Talk: D. An, Harvard Medical School, USA
A bacterial symbiosis molecule defines host intestinal natural killer T cell homeostasis [O10]
16:55 - 17:30 Fergus Shanahan, University College Cork, Ireland
Mining the microbiome for new therapeutics [Inv.17]
17:30 - 17:35 Closing Remarks
17:35 – 18:00 Networking Coffee Break




Supporting Publications

Cell Host & Microbe
Trends in Parasitology
Trends in Immunology
Trends in Microbiology